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: ߧڧާ֧ݧڧ (4-ߧڧ-2-֧ߧܧڧ֧ߧڧݧާ֧ѧߧݧߧѧާڧ) ߧ ԧ . ֧ݧ֧ܧڧӧߧ ڧߧԧڧҧڧ֧ -2 ߧ֧٧ߧѧڧ֧ݧߧ ֧֧ߧ -1, ӧ٧ ֧ ڧ٧ҧڧѧ֧ݧߧ ާ٧ڧ ڧߧ֧ ѧԧݧѧߧէڧߧ, ڧߧէڧӧѧߧߧ ӧѧݧڧ֧ݧߧ ֧ѧܧڧ֧. ا ӧ֧ާ ާڧߧڧާѧݧߧ ӧݧڧ֧ ߧ ڧߧ֧ ֧ԧݧߧ ѧԧݧѧߧէڧߧ, ڧ-٧ ֧ԧ ҧߧ ֧ѧܧڧ, ҧ֧ߧߧ ߧ ڧ֧ӧѧڧ֧ݧߧԧ ѧܧ, ӧѧا֧ߧ ާڧߧڧާѧݧߧ. ܧѧ٧ӧѧ֧ ڧӧӧѧݧڧ֧ݧߧ, ѧߧѧݧԧ֧٧ڧ֧ اѧߧڧاѧ֧ է֧ۧӧڧ. ߧԧڧҧڧ֧ ڧߧ֧ ѧԧݧѧߧէڧߧ ѧԧ ӧѧݧ֧ߧڧ, ݧ֧ۧܧڧ֧ߧ, ѧܧ ѧܧڧӧѧڧ ާҧڧ, ֧ԧݧڧ ާڧԧѧڧ ߧ֧ۧڧݧߧ ԧѧߧݧڧ ֧֧ ߧէ֧ݧڧ է, ާ֧ߧѧ֧ ӧ ԧڧѧާڧߧ ڧ ߧ ܧݧ֧, ѧߧ ӧѧݧ֧ߧڧ ֧, է֧ۧӧڧ ѧܧ ߧ֧ܧ٧ ݧ (TNF‑), ҧӧ֧ԧ ߧѧܧݧ֧ߧڧ ҧѧէڧܧڧߧڧߧ ڧܧڧߧ, ӧ٧ӧѧڧ ҧݧ. ֧ѧѧ ߧڧاѧ֧ ѧԧ֧ԧѧڧ ѧߧڧߧ ֧ܧڧէ ٧֧ݧާ ݧ֧ۧܧڧѧާ, ߧ ӧݧڧ ߧ ڧ ѧԧڧѧߧ ѧܧڧӧߧ ֧էӧѧѧ էѧݧߧ֧ۧ ѧݧ֧ѧڧ. ڧާ֧ݧڧ ڧߧԧڧҧڧ֧ ܧݧݧѧԧ֧ߧѧ٧ ާ֧ѧݧݧ֧ѧ٧, ާ֧ߧѧ է֧ԧѧէѧڧ ֧էӧѧѧ ԧ֧ڧӧѧߧڧ ֧ѧڧ. ӧѧӧѧ֧ ڧ֧ӧѧڧ֧ݧߧ ѧܧ ߧ֧٧ѧӧڧڧާ ڧ֧ާ ڧ, ҧ ѧ֧է֧ݧ֧ ܧѧߧ ҧڧݧԧڧ֧ܧڧ اڧէܧ ԧѧߧڧ٧ާ. ڧާ֧ݧڧ ҧݧѧէѧ֧ էӧ ҧ֧ݧܧѧާ ݧѧ٧ާ ܧӧ. ֧ѧѧ ާاߧ ߧѧ٧ߧѧѧ էԧڧާ ֧ѧѧѧާ, ߧ ѧѧ ڧ ӧ٧ѧڧާէ֧ۧӧڧ. ֧ڧ ݧӧӧ֧է֧ߧڧ ߧڧާ֧ݧڧէ 5C6 . ֧ѧѧ ߧ ܧާݧڧ֧ ԧѧߧڧ٧ާ ߧ ܧѧ٧ӧѧ֧ ܧڧ֧ܧԧ է֧ۧӧڧ. ڧާ֧ݧڧ ѧܧڧ֧ܧ ݧߧ ާ֧ѧҧݧڧ٧ڧ֧ ֧֧ߧ, 1C3% ֧ԧ ߧ֧ڧ٧ާ֧ߧ֧ߧߧ ӧڧէ ӧӧէڧ ާ. : ֧ӧާѧڧէߧ ѧڧ, ֧ѧڧ, ֧ѧ, ڧѧڧ֧ܧڧ ѧڧ, էѧԧ, ҧڧ, ֧ߧէڧߧڧ, ֧ߧէӧѧԧڧߧڧ, ҧݧ֧ӧ ڧߧէ ѧ٧ݧڧߧ ڧݧԧڧ, ڧݧ ԧڧߧ֧ܧݧԧڧ֧ܧڧ ٧ѧҧݧ֧ӧѧߧڧ, ҧݧ֧ӧ ڧߧէ ֧ӧڧߧ էڧާ֧ߧ֧, ҧݧ ݧ֧֧ѧڧߧߧ ֧ڧ, ѧӧާѧ. : ӧߧ ӧ٧ݧ 0,1 2 ѧ٧ ܧ ݧ ֧է. ֧ ӧ٧ѧ ѧ 12 ݧ֧ 0,005 /ܧ ܧ 2 ڧ֧ާ. : ԧѧڧ, ԧѧէѧէ֧ߧڧ, ٧ڧ ٧ӧ ا֧ݧէܧ /ڧݧ էӧ֧ߧѧէѧڧ֧ߧ ܧڧܧ, ӧѧا֧ߧߧ ߧѧ֧ߧڧ ߧܧڧ ֧֧ߧ ֧ (ܧݧڧ֧ߧ ܧ֧ѧڧߧڧߧ ާ֧ߧ֧ 30 ާ/ާڧ), ӧ֧ߧߧѧ ڧߧէڧӧڧէѧݧߧѧ ӧӧڧ֧ݧߧ ܧާߧ֧ߧѧ ֧ѧѧ, ֧ڧ ҧ֧֧ާ֧ߧߧ ܧާݧ֧ߧڧ ԧէ; է֧ܧڧ ӧ٧ѧ է 12 ݧ֧. : ҧߧ ֧էܧ ݧѧҧ ӧѧا֧ߧ, ߧ ӧ֧ާ֧ߧߧ ѧѧܧ֧ , ܧѧ ѧӧڧݧ, ߧ ֧ҧ ާ֧ߧ ֧ѧѧ. ٧ާاߧ ڧ٧اԧ, ߧ, ҧݧ ڧԧѧѧݧߧ ҧݧѧ, ԧݧӧܧا֧ߧڧ, ѧݧݧ֧ԧڧ֧ܧڧ ֧ѧܧڧ ӧڧէ ܧاߧ , ܧ ѧ է ѧާ֧ݧߧ ߧڧا֧ߧڧ է٧ ֧ѧѧ ڧݧ ֧ԧ ާ֧ߧ. ߧԧէ ӧݧ ߧѧ֧ߧڧ ٧֧ߧڧ, ֧ҧ֧ ֧ܧѧ֧ߧڧ ڧ֧ާ ֧ѧѧ. : ܧ ݧ֧֧ߧڧ ֧ѧѧ ٧ѧӧڧڧ ܧݧڧߧڧ֧ܧ ڧѧڧ, ߧ էݧا֧ ҧ ާѧܧڧާѧݧߧ ܧܧڧ. էݧڧ֧ݧߧ ڧާ֧ߧ֧ߧڧ ߧڧާ֧ݧڧէ ߧ֧ҧէڧާ ӧէڧ ܧߧݧ ܧѧ٧ѧ֧ݧ֧ ߧܧڧߧѧݧߧԧ ߧڧ ֧֧ߧ ֧ڧէڧߧ 1 ѧ 2 ߧ֧է֧ݧ. ݧѧ ӧ֧ߧڧ ܧѧ٧ѧ֧ݧ֧ ݧ, 㧡, ֧ѧѧ ݧ֧է֧ ާ֧ߧڧ. ߧѧ٧ߧѧ֧ߧڧ ڧާ֧ݧڧէ-ѧߧڧ ҧݧߧ اڧݧԧ ӧ٧ѧ ܧ֧ܧڧ ֧اڧާ է٧ڧӧѧߧڧ ߧ ֧ҧ֧. ֧ڧ ҧ֧֧ާ֧ߧߧ ڧާ֧ߧ ڧާ֧ݧڧ-ѧߧڧ ߧ ֧ܧާ֧ߧէ֧ (ҧ֧ߧߧ III ڧާ֧) ڧ-٧ ѧߧ ֧اէ֧ӧ֧ާ֧ߧߧԧ ٧ѧܧڧ ѧ֧ڧѧݧߧԧ ܧ ݧէ ѧ٧ӧڧڧ ѧߧڧ ާѧܧ ާѧ֧. ߧ֧ҧէڧާ ߧѧ٧ߧѧ֧ߧڧ ڧާ֧ݧڧէ-ѧߧڧ ֧ڧ ܧާݧ֧ߧڧ ԧէ ݧ֧է֧ ֧ڧ ӧ ֧ܧѧ֧ߧڧ ԧէߧԧ ӧܧѧާݧڧӧѧߧڧ. ڧާ֧ݧڧ-ѧߧڧ ߧ ݧ֧է֧ ڧߧڧާѧ ا֧ݧ ߧѧ֧ߧڧ ߧܧڧ ֧֧ߧ ֧. ڧާ֧ݧڧ-ѧߧڧ ߧѧ٧ߧѧѧ اߧ ҧݧߧ ֧է֧ߧ-էڧާ ٧ѧҧݧ֧ӧѧߧڧާ, ӧܧݧѧ . ٧ާاߧ ֧էѧݧا֧ߧߧ ܧӧ֧֧ߧڧ ߧ ߧ ݧ֧֧ߧڧ ѧߧڧܧѧԧݧߧѧާ ѧߧڧѧԧ֧ԧѧߧѧާ. ڧ֧ާ ֧ѧѧ ߧ ֧ܧާ֧ߧէ֧ ѧӧݧ ѧߧߧާ ֧էӧѧާ ٧ѧߧڧާѧ էԧڧާ ֧ߧڧѧݧߧ ѧߧާ ӧڧէѧާ է֧֧ݧߧ, ֧ҧڧާ ҧ ڧާߧ ֧ѧܧڧ. : ڧާ֧ݧڧ-ѧߧڧ ҧݧѧէѧ֧ ӧܧڧ էӧ ҧ֧ݧܧѧާ ݧѧ٧ާ ܧӧ, ާ ާا֧ ֧ӧӧѧ ӧ٧ӧѧߧڧ էԧڧ, ڧߧ էߧӧ֧ާ֧ߧߧ ڧާ֧ݧڧէ-ѧߧڧ, ݧ֧ܧѧӧ֧ߧߧ ֧է ҧ֧ݧܧѧާ ݧѧ٧ާ ܧӧ ڧ٧ާ֧ߧ ڧ ѧާѧܧܧڧߧ֧ڧ֧ܧڧ ڧݧ. ڧާ֧ݧڧ-ѧߧڧ ڧݧڧӧѧ֧ է֧ۧӧڧ ѧߧڧܧѧԧݧߧ, ӧѧ֧ ӧ֧ߧ ݧڧڧ ݧѧ٧ާ ܧӧ. ާ֧֧ߧ ܧݧڧߧڧ֧ܧ ٧ߧѧڧާԧ ӧ٧ѧڧާէ֧ۧӧڧ ڧާ֧ݧڧէ-ѧߧڧ ֧ާڧէ, ӧѧѧڧߧ, էڧԧܧڧߧ, ֧ڧݧݧڧߧ, ԧݧڧҧ֧ߧܧݧѧާڧէ, ڧާ֧ڧէڧߧ, ѧߧѧڧէѧާ. : ѧ ӧ֧ԧ ֧֧է٧ڧӧܧ ӧݧ֧ ҧݧ ڧԧѧѧݧߧ ҧݧѧ, ߧ, ӧ, ӧ٧ާاߧ ߧѧݧڧڧ اڧݧ ܧӧ ӧߧ ާѧѧ. ѧܧا ӧ٧ާاߧ ԧݧӧߧѧ ҧݧ, ԧݧӧܧا֧ߧڧ, ٧ѧާا֧ߧߧ, ѧۧӧ ѧާ, է֧٧ڧ֧ߧѧڧ, ֧ ٧ߧѧߧڧ ӧݧ֧ߧڧ ԧ֧ߧ֧ѧݧڧ٧ӧѧߧߧ է. ߧ֧ڧڧѧݧߧ ߧ֧ڧ, ߧ֧ڧ֧ܧڧ ڧߧէ, ѧڧݧݧߧ ߧ֧ܧ. ӧ֧ߧڧ ӧߧ ѧާڧߧѧߧ֧ѧ ӧܧ ܧӧ, ا֧ݧߧ ܧݧ֧ ӧէ֧ݧ֧ߧڧ ݧڧ٧ڧ ҧݧ֧, ԧ֧ѧڧ. ֧֧ߧڧ ԧ ѧӧݧ֧ߧڧ ڧ ڧݧ٧ӧѧߧڧ էէ֧اڧӧѧ֧ ڧާާѧڧ֧ܧ ֧ѧڧ. ڧӧѧߧߧ էڧ֧ ܧѧܧѧݧߧ ԧ֧ާէڧѧݧڧ ާѧݧ֧ܧڧӧߧ ڧ-٧ ٧ߧѧڧ֧ݧߧ ֧֧ߧ ӧ٧ӧѧߧڧ ֧ѧѧ ҧ֧ݧܧѧާ ݧѧ٧ާ ܧӧ. ֧ާ֧٧ڧ ѧܧا ާѧݧ֧ܧڧӧߧ. ֧ڧڧ֧ܧԧ ѧߧڧէ ߧ֧. : , ٧ѧڧ֧ߧߧ ӧ֧ ާ֧ ֧ާ֧ѧ է 25 㧳.